Carbazeran 是一种有效的磷酸二酯酶抑制剂，是醛氧化酶的底物。
| Cas No. | 70724-25-3 |
| 别名 | 卡巴折伦 |
| Canonical SMILES | COC1=C(OC)C=C(C=NN=C2N3CCC(OC(NCC)=O)CC3)C2=C1 |
| 分子式 | C18H24N4O4 |
| 分子量 | 360.4 |
| 溶解度 | Chloroform: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM). It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria, respectively. Carbazeran is also a substrate for the enzyme aldehyde oxidase (AOX1), which is involved in the metabolism of xenobiotics. |
