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11β-Prostaglandin E2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
11β-Prostaglandin E2图片
CAS NO:38310-90-6
包装与价格：
包装价格(元)
500μg询价
1mg询价
5mg询价
10mg询价

11β-Prostaglandin E2 (11β-Dinoprostone) 是一种前列腺素衍生物，可抑制 [3H]PGE2 与大鼠下丘脑膜的结合，Ki 为 53.3 nM。
Cas No.38310-90-6
别名11β-前列腺素E2; 11β-Dinoprostone; 11β-PGE2
化学名9-oxo-11β,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid
Canonical SMILESO=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@@H](O)C1
分子式C20H32O5
分子量352.5
溶解度>100 mg/ml (from PGE2) in DMSO, >100 mg/ml (from PGE2) in DMF, >100 mg/ml (from PGE2) in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3]

Reference:
[1]. Dray, F., and Heaulme, M. Prostaglandins of the E series inhibit release of noradrenaline in rat hypothalamus by a mechanism unrelated to classical α2 adrenergic presynaptic inhibition. Neuropharmacology 23, 457-462 (1984).
[2]. Raisz, L.G., and Woodiel, F.N. Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. Prostaglandins 37, 229-235 (1989).
[3]. Itoh, S., Lu, R., Bao, Y., et al. Structural determinants of substrates for the prostaglandin transporter PGT. Molecular Pharmacology 50, 736-742 (1996).

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