亚胺培南（水合物）是硫霉素的稳定结晶衍生物，是一种抗生素，对广泛的革兰氏阳性和革兰氏阴性需氧和厌氧细菌具有优异的活性。
| Cas No. | 74431-23-5 |
| 别名 | 亚胺培南一水物; N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate |
| Canonical SMILES | [H][C@@]1([C@@]([H])([C@H](O)C)C2=O)N2C(C(O)=O)=C(SCCNC=N)C1.O |
| 分子式 | C12H17N3O4S•H2O |
| 分子量 | 317.4 |
| 溶解度 | PBS (pH 7.2): 2 mg/ml |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Imipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3]. References:
[1]. Zhanel GG, et al. Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects. Can J Infect Dis. 1998 Jul;9(4):215-28.
[2]. Jacoby GA, et al. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82.
[3]. Balibar CJ, et al. cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology. 2010 May;156(Pt 5):1372-83. |
