Hygrolidin 是由吸水链霉菌 D-1166 生产的 16 元大环内酯类抗生素。
| Cas No. | 83329-73-1 |
| Canonical SMILES | C/C1=C\C=C\[C@H](OC)[C@]([C@@H](C)[C@@H](O)[C@H](C)[C@]2(O)O[C@H](CC)[C@H](C)[C@H](OC(/C=C/C(O)=O)=O)C2)([H])OC(/C(C)=C\C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C1)=O |
| 分子式 | C38H58O11 |
| 分子量 | 690.9 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively). |
