Fosfomycin (MK-0955) tromethamine 是一种可穿透血脑屏障的广谱抗生素，通过不可逆地抑制细胞壁合成的早期阶段。
| Cas No. | 78964-85-9 |
| 别名 | 磷霉素氨丁三醇; MK-0955 tromethamine |
| Canonical SMILES | C[C@H]1[C@@H](P(O)(O)=O)O1.OCC(CO)(N)CO |
| 分子式 | C4H11NO3•C3H7O4P |
| 分子量 | 259.2 |
| 溶解度 | Ethanol: Slightly Soluble,Water: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fosfomycin trometamol is a broad-spectrum antibiotic that is active against Gram-negative and Gram-positive bacteria with MIC90 values of 8, 32, 4, and 32 µg/mL for ESBL E. coli, carbapenemase-producing K. pneumoniae, P. mirabilis, and methicillin-resistant S. saprophyticus, respectively, in a broth microdilution assay. It is an inhibitor of uridine diphospho-N-acetyl-D-glucosamine enolpyruvyl transferase (MurA) that enters cells via the glycerol-3-phosphate and hexose-6-phosphate transporters. Formulations containing fosfomycin trometamol have been used in the treatment of urinary tract infections. |
