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Emtricitabine S-oxide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Emtricitabine S-oxide图片
CAS NO:152128-77-3
包装与价格:
包装价格(元)
1mg询价
5mg询价
10mg询价

恩曲他滨 S-氧化物 (Emtricitabine sulfoxide) 是恩曲他滨的主要降解产物。
Cas No.152128-77-3
别名恩曲他滨S-氧化物(非对映体混合物),Emtricitabine sulfoxide; Emtricitabine Degradant-III
Canonical SMILESO=C1N([C@H]2O[C@@H](CO)S(C2)=O)C=C(F)C(N)=N1
分子式C8H10FN3O4S
分子量263.2
溶解度Water: heated, slightly
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Emtricitabine S-oxide (Emtricitabine sulfoxide) is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.

Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III)[1].

References:
[1]. A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.

 
 
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