Tolcapone D7 (Ro 40-7592 D7) 是 Tolcapone 的氘代物。Tolcapone 是一种选择性，有效和口服的COMT抑制剂。Tolcapone 还是一种α-syn和Aβ42寡聚和原纤维形成的有效抑制剂，可防止 PC12 细胞中这两种蛋白质聚集引起的细胞外毒性。
| 生物活性 | Tolcapone D7 (Ro 40-7592 D7) is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally activeCOMTinhibitor. Tolcapone is also a potent inhibitor ofα-synandAβ42 oligomerizationandfibrillogenesisand protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2]. |
| IC50& Target | COMT[1]
α-syn and Aβ42 oligomerization, fibrillogenesis[2] |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
