BMT-124110 is a potent, selectiveAAK1inhibitor with anIC₅₀of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) andCyclin G-associated kinase (GAK)with IC₅₀s of 17 and 99 nM, respectively^[1].

BMT-124110 shows a cellular IC₅₀of 3.2±1.4 nM for AAK1^[1].

BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals^[1].

369.46

C₂₁H₂₇N₃O₃

1679371-59-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.