Ph-HTBA is a high-affinity, brain-penetrating modulator forCaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with aK_dvalue of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders^[1].

Kd: 757 nM (CaMKIIα)^[1]

Ph-HTBA can inhibit HOCPCA binding with a K_ivalue of 1.4 μM^[1].
Ph-HTBA has binding affinity for CaMKIIα with a K_dvalue of 757 nM^[1].
Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding^[1].

Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice^[1].

294.34

C₁₉H₁₈O₃

2368927-41-5

Room temperature in continental US; may vary elsewhere.

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