Tacrine hydrochloride is a potent inhibitor of bothAChEandBChE, withIC₅₀s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also aNMDARinhibitor, with anIC₅₀of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease^[1][2].

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)^[1][2]

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner^[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC₅₀of ~500 μM^[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC₅₀of ~190 μM at -60 mV^[2].

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice^[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice^[3].

234.72

Solid

C₁₃H₁₅ClN₂

1684-40-8

盐酸他克林；四氢氨基吖啶

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

H₂O : 33.33 mg/mL(142.00 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 16.67 mg/mL (71.02 mM); Clear solution; Need ultrasonic