BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) withIC₅₀values of 50 to 70mg/kg in various rat brain regions.

IC50: 50-70mg/kg (FAAH, rat brain regions)^[1]

ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC₅₀s of 50-70mg/kg (i.p.) in various brain regions. IC₅₀values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)^[1].

In January 2016, severe adverse events (SAE) occurs in the Phase I clinical trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought^[2].

300.36

Solid

C₁₆H₂₀N₄O₂

1233855-46-3

Room temperature in continental US; may vary elsewhere.

DMSO : 2.2 mg/mL(7.32 mM;Need ultrasonic)

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