ML-191 是GPR55的拮抗剂。它抑制溶血磷脂酰肌醇诱导的 GPR55 信号传导（在过度表达 GPR55 的 U2OS 细胞中EC50=1.076 μM）。ML-191 抑制 LPI 诱导的 ERK1/2 磷酸化 (IC50=328 nM) 。当使用浓度为 30 μM 时，ML-191 抑制 PKCβII 的受体依赖性易位。
| 生物活性 | ML-191 is an antagonist ofGPR55. It inhibitsGPR55signaling induced by lysophosphatidylinositol (EC50=1.076 μM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 μM[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
