Nrf2/HO-1 activator 1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Nrf2/HO-1 activator 1 (Compound 24) 是一种有效的Nrf2/HO-1激活剂、神经保护剂。Nrf2/HO-1 activator 1 具有神经保护和抗氧化的活性。Nrf2/HO-1 activator 1 可用于帕金森病 (PD) 的研究。

生物活性

Nrf2/HO-1 activator 1 (Compound 24) is a potentNrf2/HO-1activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research^[1].

体外研究
(In Vitro)

Nrf2/HO-1 activator 1 (0.3-30 μM; 24 h) exhibits potent neuroprotection in both 6-OHDA- and rotenone-induced cell death models^[1].
Nrf2/HO-1 activator 1 (1-30 μM; 6 h) increases HO-1 expression in PC12 cells^[1].
Nrf2/HO-1 activator 1 (12 μM; 1-12 h) increases phosphorylation of ERK1/2, JNK, and Akt in PC12 cells^[1].

Cell Viability Assay^[1]

Cell Line:	PC12 cells
Concentration:	0.3, 1, 3, 10, and 30 μM
Incubation Time:	4 hours
Result:	Inhibited 6-OHDA-induced toxicity with IC₅₀of 3.9 μM. Inhibited rotenone-induced toxicity with IC₅₀of 4.8 μM.

Western Blot Analysis^[1]

Cell Line:	PC12 cells
Concentration:	10 μM
Incubation Time:	1, 3, 6, and 12 hours
Result:	Induced phosphorylation of ERK1/2, JNK, and Akt.

Western Blot Analysis^[1]

Cell Line:	PC12 cells
Concentration:	1, 3, 10, and 30 μM
Incubation Time:	6 hours
Result:	Increased HO-1 expression in a dose-dependent manner, with 2-fold increases at 30 μM concentrations.

体内研究
(In Vivo)

Nrf2/HO-1 activator 1 inhibits the production of lipid peroxide in rat brain homogenates by 50.5% at 100 μM^[1].

分子量

350.36

Formula

C₂₁H₁₈O₅

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.