MELK-8a (NVS-MELK8a) 是一种高效的选择性母体胚胎亮氨酸拉链激酶 (MELK) 抑制剂，IC50为 2 nM。MELK-8a 还抑制 Flt3 (ITD)、Haspin、PDGFRα，IC50分别为 0.18、0.19 和 0.42 μM。 MELK 在调节癌细胞的细胞有丝分裂中发挥着重要作用。
| 生物活性 | MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50of 2 nM. MELK-8a also inhibitsFlt3(ITD), Haspin,PDGFRαwith IC50s of 0.18, 0.19, and 0.42 μM, respectively.MELKplays an essential role in regulating cell mitosis in a subset ofcancercells[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
