PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selectivePDK1inhibitor with aK_dof 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 byPDK1^[1].

Kd: 9 μM (PDK1)^[1]

PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions^[1].

380.89

Solid

C₁₅H₉ClN₂O₂S₃

1643958-89-7

Room temperature in continental US; may vary elsewhere.

DMSO : 125 mg/mL(328.18 mM;Need ultrasonic)

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