PIKfyve-IN-1

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PIKfyve-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2857982-26-2

PIKfyve-IN-1 是一种高效且具有细胞活性的化学探针，可抑制 3 磷酸磷脂酰肌醇 5-激酶 (PIKfyve)，IC₅₀值为 6.9 nM。PIKfyve-IN-1 可用于病毒学中 PIKfyve 的研究。

生物活性

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibitsphosphatidylinositol-3phosphate 5-kinase (PIKfyve)withIC₅₀value of 6.9 nM. PIKfyve-IN-1 can be used for the research ofPIKfyvein virology^[1].

IC₅₀& Target

IC50: 6.9 nM (PIKfyve)^[1]

体外研究
(In Vitro)

PIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC₅₀values of 6.9 nM and 4.01 nM, respectively^[1].
PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry^[1].
PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC₅₀values of 23.5 nM and 19.5 nM, respectively^[1].
PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis^[1].

Immunofluorescence^[1]

Cell Line:	Calu-3 cells
Concentration:	1 μM
Incubation Time:	1 h
Result:	Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein.

分子量

331.41

Formula

C₂₀H₂₁N₅

CAS 号

2857982-26-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.