VO-OHPic 是一种可逆的、非竞争性的、选择性的PTEN抑制剂，IC50为 46 nM。在 doxorubicin 诱导的心肌病中，VO-OHPic 可减少细胞凋亡 (apoptosis)、不良的心脏重塑和促炎 M1 巨噬细胞。VO-OHPic 抑制细胞自噬 (autophagy)。
| 生物活性 | VO-OHPic is a reversible, noncompetitive and selectivePTENinhibitor with anIC50of 46 nM. VO-OHPic attenuatesapoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibitsautophagy[1][2][3]. |
| IC50& Target | |
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
