AUTAC1

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AUTAC1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2241669-09-8

AUTAC1是一种MetAP2靶向自噬介导降解体 (AUTAC)。AUTACs 包含一个降解标签和一个弹头确保靶向特异性。AUTAC1 包含一个 FBnG 和一个 Fumagillol 部分。Fumagillol 共价结合到 MetAP2 上。

生物活性

AUTAC1 is aMetAP2-targeting autophagy-mediated degrader (AUTAC).AUTACscontain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2^[1].

体外研究
(In Vitro)

AUTAC1 (1-100 μM, 24 h) silences endogenous MetAP2 in hela cells^[1].

Western Blot Analysis^[1]

Cell Line:	HeLa cells.
Concentration:	1-100 μM.
Incubation Time:	24 h.
Result:	Silenced endogenous MetAP2.

分子量

931.08

Formula

C₄₄H₆₃FN₈O₁₁S

CAS 号

2241669-09-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.