SNIPER(TACC3)-11 是一种有效的成纤维细胞生长因子受体 3 转化酸性卷曲螺旋蛋白 3 (FGFR3-TACC3)抑制剂。SNIPER(TACC3)-11 降低 FGFR3-TACC3 蛋白水平，抑制 FGFR3-TACC3 阳性癌细胞的生长。
| 生物活性 | SNIPER(TACC3)-11 is a potentFGFR3-TACC3degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positivecancercells[1]. |
| IC50& Target | |
体外研究
(In Vitro) | SNIPER(TACC3)-11 (compound 5a) (0.3-3 μM; 6 hours) reduces FGFR3-TACC3 levels[1].
SNIPER(TACC3)-11 (0.3-3 μM; 72 hours) inhibits the growth of RT4 cells at 3 μM, and does not inhibit the growth of HeLa cells[1].
Western Blot Analysis | Cell Line: | RT4 cells[1] | | Concentration: | 0.3, 1 and 3 μM | | Incubation Time: | 6 hours | | Result: | Reduced FGFR3-TACC3 levels. |
Cell Proliferation Assay | Cell Line: | RT4 and HeLa cells[1] | | Concentration: | 0.3, 1 and 3 μM | | Incubation Time: | 72 hours | | Result: | Dramatically inhibited the growth of RT4 cells at 3 μM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
