Desmorpholinyl Quizartinib-PEG2-COOH 包含靶蛋白 FLT-3 配体和一种基于 PEG 的 PROTAC Linker。Desmorpholinyl Quizartinib-PEG2-COOH 可用于合成 PROTAC FLT-3 degrader 1 (HY-114323)。PROTAC FLT-3 degrader 1 是 PROTACFLT-3 ITD降解剂，IC50为 0.6 nM。
| 生物活性 | Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand forFLT-3, and a PEG-basedPROTAClinker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis ofPROTACFLT-3 degrader 1 (HY-114323).PROTACFLT-3 degrader 1 is aPROTACFLT-3internal tandem duplication (ITD)degrader with anIC500.6 nM[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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