BMS-1166-N-piperidine-CO-N-piperazine

首页蛋白库基因库产品会员服务

位置：首页 > 产品库 > BMS-1166-N-piperidine-CO-N-piperazine

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2447066-14-8

BMS-1166-N-piperidine-CO-N-piperazine 包含靶蛋白 PD-1/PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine 可用于合成 PROTAC PD-1/PD-L1 降解剂 (HY-131183)。PROTAC PD-1/PD-L1 degrader-1 抑制 PD-1/PD-L1 相互作用，IC₅₀值为 39.2 nM。

生物活性	BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand forPD-1/PD-L1immune checkpoint, and aPROTAClinker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTACPD-1/PD-L1degrader-1 (HY-131183). PROTACPD-1/PD-L1degrader-1 inhibitsPD-1/PD-L1interaction with an IC₅₀of 39.2 nM^[1].
体外研究 (In Vitro)	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
分子量	707.26
Formula	C₄₁H₄₃ClN₄O₅
CAS 号	2447066-14-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.