K-Ras ligand-Linker Conjugate 1

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K-Ras ligand-Linker Conjugate 1 包含靶蛋白K-Ras配体和 PROTAC linker，可募集 E3 连接酶 (如 VHL，CRBN，MDM2 和 IAP 等类型)。K-Ras ligand-Linker Conjugate 1 可用于合成 PROTAC K-Ras Degrader-1 (HY-129523)，PROTAC K-Ras Degrader-1 是一种有效的 PROTAC K-Ras 降解剂，在 SW1573 中对 K-Ras 的降解率 ≥70%。

生物活性	K-Rasligand-Linker Conjugate 1 incorporates a ligand forK-Ras, and aPROTAClinker, which recruitE3 ligases(such as VHL, CRBN,MDM2, and IAP).K-Rasligand-Linker Conjugate 1 can be used in the synthesis ofPROTACK-Ras Degrader-1 (HY-129523), which is potentPROTACK-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells^[1].
体外研究 (In Vitro)	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
分子量	826.94
Formula	C₄₃H₅₄N₈O₉
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.