MRTX849 ethoxypropanoic acid 包含 KRAS G12C 配体和 PROTAC 连接物。MRTX849 ethoxypropanoic acid 可用于合成 PROTAC LC-2 (HY-137516)。LC-2 是一种有效且首创的 PROTAC，能够降解内源性 KRAS G12C (DC50，介于0.25 和 0.76 μM 之间)。
| 生物活性 | MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and aPROTAClinker. MRTX849 ethoxypropanoic acid can be used in the synthesis ofPROTACLC-2 (HY-137516). LC-2 is a potent and first-in-classPROTACcapable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
