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ALK5-IN-29
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ALK5-IN-29图片
CAS NO:2785430-85-3

ALK5-IN-29 是一种选择性的激活素受体样激酶 (ALK) 抑制剂。 ALK5-IN-29 可以抑制激活素受体样激酶的活性，IC50值 ≤10 nM。AALK5-IN-29 还具有抑制肿瘤生长的作用，可用于癌症等增殖性疾病的研究。
生物活性

ALK5-IN-29 is an selectiveactivin receptor-like kinase (ALK)inhibitor. ALK5-IN-29 can inhibit the activity ofALK5with anIC50value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such ascancer[1].

IC50& Target

IC50: ≤10 nM (ALK5/2); ≤100 nM (RD-SMAD receptor)[1]

体外研究
(In Vitro)

ALK5-IN-29 (EX-06) has kinase inhibition of ALK5 with an IC50value of ≤10 nM[1].
ALK5-IN-29 has kinase selectivity of ALK2/ALK5 with an IC50value of ≤10 nM[1].
ALK5-IN-29 shows TGFB-RI inhibition (RD-SMAD receptor activity) with an IC50value of ≤100 nM[1].

分子量

444.51

Formula

C24H25FN8

CAS 号

2785430-85-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

 
 
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