KYL peptide, an antagonistic peptide, selectively targetsEphA4receptor. KYL peptide binds to the ligand-binding domain ofEphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses^[1][2].

EphA4 receptor^[1]

KYL peptide blocks the extracellular ligand-binding domain of EphA4, abolishes the Aβ-stimulated EphA4 tyrosine phosphorylation^[2].
KYL peptide abolishes the Aβ-triggered reduction of dendritic spines in cultured hippocampal neurons^[2].

1465.73

C₇₄H₁₀₈N₁₄O₁₇

676657-00-4

KYLPYWPVLSSL

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