Insulin degludec

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Insulin degludec

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

844439-96-9

Insulin degludec 是一种超长效形式的胰岛素，用于治疗 1 型和 2 型糖尿病引起的高血糖。Insulin degludec 结合胰岛素受体的IC₅₀值为 19.59 nM/L。Insulin degludec 可用于 1 型和 2 型糖尿病的研究。

生物活性

Insulindegludec is an ultra-long-acting form ofinsulinused for the treatment of hyperglycemia caused by type 1 and type 2 dabetes.Insulindegludec shows binding efficiency with anIC₅₀value of 19.59 nM/L forinsulin receptor.Insulindegludec can be used for the research of type 1 and type 2 diabetes^[1]^[2].

IC₅₀& Target

IC50: 19.59 nM/L (insulin receptor)^[2]

体外研究
(In Vitro)

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC₅₀value of 19.59 nM/L^[2].
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells^[2].

Western Blot Analysis^[2]

Cell Line:	HL-1 cardiomyocytes
Concentration:	200 nM
Incubation Time:	0-60 min
Result:	Decreased the level of Akt phosphorylation after 5 and 10 min treatment.

体内研究
(In Vivo)

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia^[1].

Animal Model:	Male Swiss mice with diabetes^[1]
Dosage:	5 U/kg
Administration:	Subcutaneous injection; 5 U/kg once daily for 30 days
Result:	Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.

Clinical Trial

性状

Solid

CAS 号

844439-96-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)