S961 acetate

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S961 acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

S961 acetate 是一种高亲和力的胰岛素受体 (insulin receptor, IR) 拮抗剂，对 HIR-A，HIR-B 和人胰岛素样生长因子 I 受体 (HIGF-IR) 的IC₅₀分别为 0.048，0.027 和 630 nM。

生物活性

S961 acetate is an high-affinity and selectiveinsulin receptor(IR) antagonist withIC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and humaninsulin-like growth factor Ireceptor (HIGF-IR) in SPA-assay, respectively^[1].

体外研究
(In Vitro)

S961 also shows high-affinity to Rat IR and Pig IR with IC₅₀s of 0.056 nM and 0.084 nM in PEG-assay, respectively^[1].

分子量

4864.18

性状

Solid

Formula

C₂₁₃H₃₀₁N₅₅O₇₂S₂

Sequence

Gly-Ser-Leu-Asp-Glu-Ser-Phe-Tyr-Asp-Trp-Phe-Glu-Arg-Gln-Leu-Gly-Gly-Gly-Ser-Gly-Gly-Ser-Ser-Leu-Glu-Glu-Glu-Trp-Ala-Gln-Ile-Gln-Cys-Glu-Val-Trp-Gly-Arg-Gly-Cys-Pro-Ser-Tyr (Disulfide bridge: Cys33-Cys40)

Sequence Shortening

GSLDESFYDWFERQLGGGSGGSSLEEEWAQIQCEVWGRGCPSY (Disulfide bridge: Cys33-Cys40)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 12.5 mg/mL(2.57 mM;Need ultrasonic)

H₂O : 1.79 mg/mL(0.37 mM;ultrasonic and adjust pH to 8 with NaOH)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.2056 mL	1.0279 mL	2.0558 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。