ITK inhibitor 6

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ITK inhibitor 6

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CAS NO:

2404604-06-2

ITK inhibitor 6 (compound 43) 是一种有效的选择性ITK抑制剂，ITK、BTK、JAK3、EGFR、LCK 的IC₅₀s 分别为 4 nM、133 nM、320 nM、2360 nM、155 nM。ITK inhibitor 6 抑制 PLCγ1 和 ERK1/2 的磷酸化。ITK inhibitor 6 具有抗增殖活性。

生物活性	ITK inhibitor6 (compound 43) is a potent and selectiveITKinhibitor withIC₅₀s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM forITK,BTK,JAK3,EGFR, LCK, respectively.ITK inhibitor6 inhibits phosphorylation of PLCγ1 and ERK1/2.ITK inhibitor6 shows antiproliferative activities^[1].
IC₅₀& Target	IC₅₀: 4 nM (ITK); 133 nM (BTK), 320 nM (JAK3), 2360 nM (EGFR), 155 nM (LCK)^[1]
体外研究 (In Vitro)	ITK inhibitor 6 (compound 43) shows antiproliferative activities with GI₅₀s of 5.1, 3.7, 3.4, 5.4, 19 μM for Jurkat, Molt-4, CCRF-CEM, H9, HEK 293 T cells, respectively^[1]. ITK inhibitor 6 docks into the ATP-binding site of ITK and BTK^[1].
分子量	486.51
Formula	C₂₈H₂₄F₂N₄O₂
CAS 号	2404604-06-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.