SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist ofSmoaccumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-typeSmo^[1].

Smo, SmoM2^[1]

SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC₅₀: 1.1 μM)^[1].
SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay^[1].
SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1^+/–neonates) induced by Shh^[1].

375.73

C₁₆H₂₄BrClN₂O

1177600-74-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.