CUR61414

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CUR61414

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

334998-36-6

CUR61414 是一种新型的可渗透细胞的Hedgehog信号通路抑制剂 (IC₅₀ =100-200 nM)，CUR61414 是氨基脯氨酸类化合物的小分子成员，可选择性结合Smoothened (Smo)，K_i 值为 44 nM。CUR-61414可以诱导癌细胞凋亡 (apoptosis) 而不会影响非癌症细胞。

生物活性

CUR61414 is a novel, potent and cell permeableHedgehogsignaling pathway inhibitor(IC₅₀ =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds tosmoothened (Smo)with aK_i value of 44 nM. CUR-61414 can induceapoptosisincancercells without affecting neighboring non-tumor cells^[1]^[2].

IC₅₀& Target

Hedgehog inhibitor^[1]

体外研究
(In Vitro)

CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells^[1].

体内研究
(In Vivo)

CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions^[1].

分子量

550.69

性状

Solid

Formula

C₃₁H₄₂N₄O₅

CAS 号

334998-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(181.59 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.8159 mL	9.0795 mL	18.1590 mL
5 mM	0.3632 mL	1.8159 mL	3.6318 mL
10 mM	0.1816 mL	0.9080 mL	1.8159 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。