Porcn-IN-1

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Porcn-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2036044-77-4

Porcn-IN-1 是有效的porcupine抑制剂，IC₅₀值为 0.5±0.2 nM。

生物活性

Porcn-IN-1 is potentporcupineinhibitor with anIC₅₀of 0.5±0.2 nM.

IC₅₀& Target

IC50: 0.5±0.2 nM (Porcupine inhibitor)^[1]

体外研究
(In Vitro)

Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor^[1].

体内研究
(In Vivo)

Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg)^[1].

分子量

410.44

性状

Solid

Formula

C₂₅H₁₉FN₄O

CAS 号

2036044-77-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL(243.64 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.4364 mL	12.1820 mL	24.3641 mL
5 mM	0.4873 mL	2.4364 mL	4.8728 mL
10 mM	0.2436 mL	1.2182 mL	2.4364 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。