RepSox (E-616452) (GMP) is aRepSox(HY-13012) produced by using GMP guidelines.GMP small moleculesworks appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor^[1].

IC50: ALK5 autophosphorylation (4 nM)

RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs)^[1].
RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs^[2].
RepSox (GMP) together withForskolin(HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation^[3].

287.32

Solid

C₁₇H₁₃N₅

446859-33-2

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)