Vorozole

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Vorozole

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

129731-10-8

(+)-Vorozole
R83842

Vorozole 是一种有效的，选择性的，具有口服活性的非甾体芳香酶抑制剂。Vorozole 表现出体内抗肿瘤作用。Vorozole 具有研究乳腺癌的潜力。

生物活性

Vorozole is a potent and selective, orally active non-steroidalaromataseinhibitor^[1]^[2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammarycancer^[3].

体外研究
(In Vitro)

Vorozole inhibits aromatase activity with anIC₅₀s of 1.4 nM in FSH-stimulated rat granulosa cells^[4].

体内研究
(In Vivo)

Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 dayss) shows antitumor effect and increase the release of serum insulin-like growth factor (IGF)-1 and serum testosterone levels^[3].
Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice^[4].

Animal Model:	Female Sprague-Dawley rats^[3]
Dosage:	0.08, 0.16, 0.31, 0.63 or 1.25 mg/kg
Administration:	Gavage; daily (starting at 43 days of age) for 77 days; given a single i.v. dose of methylnitrosourea (MNU) (50 mg/kg body wt) after 7 days
Result:	Caused a dose-dependent increase in body weight gain and decrease in cancer incidence, increased the insulin-like growth factor (IGF)-1, serum testosterone levels.

分子量

324.77

Formula

C₁₆H₁₃ClN₆

CAS 号

129731-10-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.