Corifollitropin alfa

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CAS NO:

195962-23-3

Org 36286
MK-8962

Corifollitropin alfa (Org 36286) 是一种长效的重组促卵泡激素 (FSH) 类似物。Corifollitropin alfa 是一种FSH Receptor激动剂，EC₅₀为 5.0 pM。Corifollitropin alfa 可刺激排卵，可用于不孕症研究。

生物活性

Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is aFSH Receptoragonist with anEC₅₀of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility^[1]^[2]^[3].

IC₅₀& Target

FSH Receptor^[2]

体内研究
(In Vivo)

Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t_1/2of 17.3 h and C_maxof 3.2 ng/mL/μg/kg in female Wistar rats^[2].
Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats^[2].
Corifollitropin alfa (3 μg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits^[3].

Animal Model:	Rats^[2]
Dosage:	2.5, 5, 10, 20, 40 μg/kg.
Administration:	Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
Result:	Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.

CAS 号

195962-23-3

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.