FSHR agonist 1 is a high affinity and allostericfollicle stimulating hormone receptor (FSHR)agonist with apEC₅₀of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR^[1].

pEC50: 7.72 (FSHR)^[1]

FSHR agonist 1 (compound 21f) 与 FSHR TMD 口袋的结合诱导 TM6 和 TM7 向内运动，这直接导致 FSHR 激活^[1]。
FSHR agonist 1 (compound 21f) 可以高效激活 FSHR、LHCGR 和 TSHR，而对 FSHR 的激活效力比 LHCGR（pEC₅₀为 6.26）和 TSHR（pEC₅₀为 6.48）高 10 倍以上^[1]。

467.62

C₂₆H₃₃N₃O₃S

1256776-89-2

Room temperature in continental US; may vary elsewhere.

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