P1075 是磺酰脲受体 2 相关的 ATP 敏感钾通道 (SUR2-KIR6) 的有效激活剂，激活 SUR2B-KIR6 通道的 EC50 值为 45 nM。
| Cas No. | 60559-98-0 |
| Canonical SMILES | N#CN/C(NC1=CC=CN=C1)=N\C(C)(C)CC |
| 分子式 | C12H17N5 |
| 分子量 | 231.3 |
| 溶解度 | DMSO:<100mM,Ethanol:<50mM |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2]. References:
[1]. Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17(19):5529-35.
[2]. Oldenburg O, et al. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35(9):1035-42. |
