Loreclezole 是一种抗癫痫化合物，是一种选择性 GABAA 受体调节剂，可作为含有 β2 或 β3 亚基的受体的正变构调节剂。
| Cas No. | 117857-45-1 |
| 别名 | 氯瑞唑,R 72063 |
| 化学名 | (E)-1-(2-chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride |
| Canonical SMILES | Cl/C(C(C(Cl)=C1)=CC=C1Cl)=C/N2N=CN=C2.Cl |
| 分子式 | C10H6Cl3N3 |
| 分子量 | 274.53 |
| 溶解度 | <1.37mg/ml in DMSO;<1.37mg/ml in ethanol |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2]. References:
[1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.
[2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. |
