8-Bromo-cGMP，钠盐，一种 cGMP 的膜可渗透类似物，是一种 PKG（蛋白激酶 G）激活剂。
| Cas No. | 51116-01-9 |
| 别名 | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐,??8-bromo-cGMP, 8-bromo Guanosine 3’,5’-cyclic monophosphate |
| 化学名 | 8-bromo-guanosine cyclic 3',5'-(hydrogen phosphate), monosodium salt |
| Canonical SMILES | BrC1=NC2=C(NC(N)=NC2=O)N1[C@@H]3O[C@@H]4[C@H]([C@H]3O)O[P@](OC4)([O-])=O.[Na+] |
| 分子式 | C10H10BrN5NaO7P |
| 分子量 | 446.09 |
| 溶解度 | 10mg in PBS(pH7.2) |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.[1] At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[2] Reference:
[1]. Rashatwar, S.S., Cornwell, T.L., and Lincoln, T.M. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: Possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 84(16), 5685-5689 (1987).
[2]. Choi, J., and Farley, J.M. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 285(2), 588-594 (1998). |
