L-701,324 是一种有效的口服活性 NMDA 受体拮抗剂，通过阻断其甘氨酸 B 结合位点来拮抗 NMDA 受体的活性。
| Cas No. | 142326-59-8 |
| 别名 | 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉 |
| 化学名 | 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one |
| Canonical SMILES | ClC1=CC=C2C(NC(C(C3=CC=CC(OC4=CC=CC=C4)=C3)=C2O)=O)=C1 |
| 分子式 | C21H14ClNO3 |
| 分子量 | 363.8 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 15 mg/ml |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.). References:
[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234 |
