SYM 2081 是一种高亲和力配体和有效的红藻氨酸受体激动剂，抑制 [3H]-红藻氨酸结合，IC50 为 35 nM，对红藻氨酸受体的选择性分别是 AMPA 和 NMDA 受体的近 3000 倍和 200 倍[1 ]。
| Cas No. | 31137-74-3 |
| 别名 | (2S,4R)-4-甲基谷氨酸 |
| 化学名 | (2S,4R)-2-amino-4-methylpentanedioic acid |
| Canonical SMILES | C[C@](C(O)=O)([H])C[C@@](N)([H])C(O)=O |
| 分子式 | C6H11NO4 |
| 分子量 | 161.16 |
| 溶解度 | <8.06mg/ml in Water |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively[1]. References:
[1]. Lee JY, et al. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Nov;150(4):546-57. |
