FGIN-1-27 是一种吲哚乙酰胺，是一种特异性的外周苯二氮卓受体 (PBR) 配体，Ki 为 5.0 nM。
| Cas No. | 142720-24-9 |
| 别名 | N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺 |
| 化学名 | 2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide |
| Canonical SMILES | FC1=CC=C(C=C1)C(NC2=CC=CC=C32)=C3CC(N(CCCCCC)CCCCCC)=O |
| 分子式 | C28H37FN2O |
| 分子量 | 436.61 |
| 溶解度 | 30mg/mL in ethanol, 20mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1] Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006). |
