(S)-(-)-5-Fluorowillardiine 是一种有效且特异性的 AMPAR 激动剂。
| Cas No. | 140187-23-1 |
| 别名 | 5-氟代尿嘧啶丙氨酸; (5S)-Fluorowillardiine; (S)-5-Fluorowillardiine |
| 化学名 | (S)-2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid |
| Canonical SMILES | FC1=CN(C(NC1=O)=O)C[C@@H](C(O)=O)N |
| 分子式 | C7H8FN3O4 |
| 分子量 | 217.16 |
| 溶解度 | Soluble to 50 mM in 1.1eq. NaOH |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist. References:
[1]. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21.
[2]. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41.
[3]. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82. |
