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7-Chlorokynurenic acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
7-Chlorokynurenic acid图片
CAS NO:18000-24-3
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
10mg询价
50mg询价
100mg询价

7-Chlorokynurenic acid (7-CKA) 是 N-甲基-D-天冬氨酸 (NMDA) 受体的甘氨酸 B 共激动剂位点的有效选择性拮抗剂 (IC50=0.56 μM)。
Cas No.18000-24-3
别名7-氯犬尿酸,7-CKA
化学名7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Canonical SMILESClC1=CC=C2C(NC(C(O)=O)=CC2=O)=C1
分子式C10H6ClNO3
分子量223.62
溶解度DMSO: slightly soluble,Ethanol: slightly soluble
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7-Chloro-4-hydroxyquinoline-2-carboxylic acid (7-Chlorokynurenic acid) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chloro-4-hydroxyquinoline-2-carboxylic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chloro-4-hydroxyquinoline-2-carboxylic acid has potent antinociceptive actions after neuraxial delivery[1][2].

Male Sprague-Dawley rats pretreated with 7-Chloro-4-hydroxyquinoline-2-carboxylic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3].

References:
[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.
[2]. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.
[3]. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.

 
 
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