L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor ofmitochondrial glutamine transport.

L-histidine completely inhibits growth and its effect on viability is inversely related toFLO11expression. L-histidine does not affect the viability of theΔflo11and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of theFLO11gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts^[1].

L-histidine (100 mg/kg) completely inhibits the brain edema in thioacetamide-treated rats^[2]. Histamine release stimulated by high K⁺from the hypothalamus in the L-histidine diet group is 60% of that in the control group. However, the concentrations of other monoamines and their metabolites are not changed by the L-histidine diet. The open-field tests show that the L-histidine diet group spends a shorter amount of time in the central zone, and the light/dark box tests demonstrate that the L-histidine diet group spends a shorter amount of time in the light box, suggesting that the L-histidine diet induced anxiety-like behaviors^[3].

155.15

Solid

C₆H₉N₃O₂

71-00-1

L-组氨酸

• Amino acids

Room temperature in continental US; may vary elsewhere.

H₂O : 20.83 mg/mL(134.26 mM;ultrasonic and warming and heat to 80℃)

DMSO : 1 mg/mL(6.45 mM;ultrasonic and warming and heat to 80℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 25 mg/mL (161.13 mM); Clear solution; Need ultrasonic