Cetrorelix Acetate

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Cetrorelix Acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

145672-81-7

醋酸西曲瑞克
SB-75 acetate

Cetrorelix Acetate (SB-75 acetate) 是GnRH受体的强效拮抗剂，其IC₅₀值为 1.21 nM。

生物活性

Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone(GnRH)receptor antagonist with anIC₅₀of 1.21 nM^[1].

IC₅₀& Target

IC50: 1.21 nM GnRH^[1].

体外研究
(In Vitro)

Cetrorelix Acetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix Acetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells^[2].

Clinical Trial

分子量

1491.09

性状

Solid

Formula

C₇₂H₉₆ClN₁₇O₁₆

CAS 号

145672-81-7

Sequence

N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2

Sequence Shortening

Ac-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-SY-{Cit}-LRPA-NH2

中文名称

醋酸西曲瑞克

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(33.53 mM;Need ultrasonic)

H₂O : 2 mg/mL(1.34 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.6707 mL	3.3533 mL	6.7065 mL
5 mM	0.1341 mL	0.6707 mL	1.3413 mL
10 mM	0.0671 mL	0.3353 mL	0.6707 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。