Saccharopine hydrochloride

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L-Saccharopine hydrochloride

Saccharopine (L-Saccharopine) hydrochloride 是赖氨酸的降解中间体，是一种线粒体毒素。赖氨酸-酮戊二酸还原酶将赖氨酸和 α-酮戊二酸转化为 Saccharopine hydrochloride。糖精脱氢酶将 Saccharopine hydrochloride 氧化为 α-氨基己酸酯半醛和谷氨酸。Saccharopine hydrochloride 通过破坏线粒体稳态而损害发育。

生物活性

Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis^[1]^[2]^[3].

IC₅₀& Target^[1]

Human Endogenous Metabolite

体外研究
(In Vitro)

Saccharopine 积累导致线粒体损伤和功能丧失，这是由C. elegans中 α-氨基己二酸半醛合酶 (AASS-1) 的糖苷脱氢酶 (SDH) 突变引起的^[1]。

体内研究
(In Vivo)

Saccharopine 积累可导致Aass突变小鼠的线粒体损伤和进行性出生后生长迟缓^[1]。

分子量

312.75

性状

Oil

Formula

C₁₁H₂₁ClN₂O₆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 250 mg/mL(799.36 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.1974 mL	15.9872 mL	31.9744 mL
5 mM	0.6395 mL	3.1974 mL	6.3949 mL
10 mM	0.3197 mL	1.5987 mL	3.1974 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。