NITD-688

立即咨询

NITD-688

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2407227-31-8

NITD-688 是一种具有口服活性的登革病毒 (dengue virus)NS4B蛋白的泛血清型抑制剂。 NITD-688 可用于登革热病毒 (DENV) 的研究。

生物活性

NITD-688 is an orally active pan-serotype inhibitor of the dengue virusNS4Bprotein. NITD-688 can be used in the research of dengue virus (DENV)^[1].

IC₅₀& Target

NS4B^[1]

体外研究
(In Vitro)

NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC₅₀values of 8 to 38 nM^[1].
NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC₅₀value of 0.94 nM^[1].
NITD-688 directly binds to wild-type but not mutant NS4B protein^[1].

体内研究
(In Vivo)

NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice^[1].
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)^[1].

Animal Model:	Infected AG129 mice^[1]
Dosage:	30 mg/kg
Administration:	Oral gavage, twice daily for 3 days
Result:	Resulted in a 1.16-log reduction in viremia.

分子量

500.68

性状

Solid

Formula

C₂₅H₃₂N₄O₃S₂

CAS 号

2407227-31-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(199.73 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9973 mL	9.9864 mL	19.9728 mL
5 mM	0.3995 mL	1.9973 mL	3.9946 mL
10 mM	0.1997 mL	0.9986 mL	1.9973 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。