首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Gramine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Gramine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Gramine图片
CAS NO:87-52-5
包装:20mg
市场价:3119元

Gramine (Donaxine) 是一种从大芦苇中分离的天然生物碱，作为活性脂联素受体 (AdipoR) 激动剂，对 AdipoR2 和 AdipoR1 的 IC50 分别为 3.2 和 4.2 μM 。
Cas No.87-52-5
别名芦竹碱,Donaxine
化学名1-(1H-indol-3-yl)-N,N-dimethylmethanamine
Canonical SMILESCN(C)CC1=CNC2=CC=CC=C21
分子式C11H14N2
分子量174.24
溶解度≥ 17.4mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].

Gramine is an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is a potential β2-AR agonist[2].Gramine (20 μM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF-7 cells), with IC50s of 9.6±0.9 and 0.1±0.1 μM, respectively[1].

References:
[1]. Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354.
[2]. Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):68-74.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024