RI(dl)-2 TFA is a potent and selectiveRAD51-mediated D-loop formationinhibitor with anIC₅₀of 11.1 μM. RI(dl)-2 TFA does not influenceRAD51binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC₅₀of 3.0 μM)^[1].

IC50: 11.1 μM (RAD51-mediated D-loop formation)^[1]

RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)^[1].
RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt^[1].

435.59

Solid

C₁₉H₁₇N₃.(1.3)C₂HF₃O₂

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)