MSC-1186 is a highly selectivepan-SRPKinhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 withIC₅₀values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research ofcancer^[1].

IC50: 2.7 nM (SRPK1), 81 nM (SRPK2), 0.6 nM (SRPK3); EC50 in HEK293T cells: 98 nM (SRPK1), 40 nM (SRPK3)^[1].

MSC-1186 对 HEK293T 细胞中的 SRPK1 和 SRPK3 具有活性，EC₅₀值分别为 98 nM 和 40 nM^[1]。
MSC-1186 对 SRPK1、SRPK2 和 SRPK3 具有活性，IC₅₀值分别为 2.7 nM、81 nM 和 0.6 nM^[1]。
MSC-1186 具有出色的全激酶组选择性^[1]。
当与 CDC2 样激酶 (CLK) 抑制剂联合使用时，MSC-1186 显示出 SR 蛋白磷酸化的累加衰减^[1]。

461.90

C₁₉H₁₇ClFN₇O₂S

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.